A Novel Approach for Testing the Hixon‐Crowel Model For In Vitro Release of Vitamin B₂ From Chitosan Coated Calcium Alginate Beads

Abstract

The dynamic release of a model drug (vitamin B₂) from chitosan coated calcium alginate beads has been studied in the media of varying pH and the Hixon‐Crowel model has been applied to the experimental data, using a novel ‘curve area measurement’ (CAM) approach. The two release profiles, namely experimental and ideal, were found to be in close agreement except for the initial phase of the release process.

Keywords:

• Hixon‐Crowel
• deviation
• vitamin B₂
• erosion