Synthesis, Structural Investigation and Biological Studies of New Macrocyclic Complexes of Tin(II)

Abstract

Macrocyclic complexes of bivalent tin were synthesized by the template condensation method using benzildihydrazone with malonic, succinic, glutaric, adipic and phthalic acids. The reaction proceeded smoothly to completion. These macrocyclic complexes were characterized by elemental analyses, molecular weight determinations, infrared and ¹H‐NMR spectral analyses. The elemental analyses are consistent with the formation of complexes [Sn(Mac_n)Cl₂] where n=1–5 and Mac represents a macrocyclic ligand moiety. All the complexes are stable in open atmosphere. The spectral studies confirmed the proposed framework of new macrocyclic complexes and indicated an octahedral geometry around the central metal atom. The complexes were screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential. The antifertility activity is also discussed with positive findings.

Keywords:

• tin(II) macrocyclic complexes
• antifungal activity
• antibacterial activity
• antifertility activity

Acknowledgement

The authors are thankful to CSIR, New Delhi, India for financial assistance in the form of grant No. 01(1956)/04/EMR‐II.