Benzo[h]quinoline based Macrocyclic Copper(II), Cobalt(II) Complexes: Synthesis, Characterization and Light induced DNA Cleavage Studies

Abstract

A new ligand dibenzo[h]quinolineno[1,3,7,9] tetraazacyclododecine-7,15 (14H, 16H)-dibenzene (L) and its Co(II)/Cu(II) metal complexes of type [MLX₂] (Where (M = Co(II) (5), Cu(II) (6) and X = Cl) were synthesized and are well characterized by FT-IR, ¹H-NMR, FAB mass elemental analysis, and electronic spectral data. The role of the cobalt/copper metals in photo-induced DNA cleavage reactions was explored by designing complex molecules having macrocyclic structure. Finally, we have shown that photocleavage of plasmid DNA is more efficiently enhanced when this macrocyclic ligand is irradiated in the presence of copper(II) than that of cobalt metal.

Keywords:

• Benzo[h]quinoline-macrocycles
• Co(II)/Cu(II) complexes
• photo-induced DNA cleavage

Acknowledgements

One of the authors (H. R. Prakash Naik) thankful to Director NMR research institute, Indian Institute of Science (IISc) Bangalore for providing spectral facilities and Sophisticated Test & Instrumentation Center, Cochin University, Kochi, Kerala, India for elemental analysis. SC/ST cell Kuvempu University for providing Junior Research Fellowship (JRF).