Biodegradable anastomotic tube prepared from diblock copolymers of mPEG-b-PLA and mPEG-b-PLGA

Abstract

During the healing and reconstruction process of digestive tract, biodegradable anastomat plays an important role. Various of materials have been explored to prepare suitable anastomat. However, the biodegradable ratio or biocompatibility could not meet the requirement of wound healing in clinical application. To overcome these obstacles, we synthetized methoxy-poly(ethylene glycol)-block-polylactide (mPEG-b-PLA) and methoxy-poly(ethylene glycol)-block-poly(lactide-co-glycolide) (mPEG-b-PLGA) with different molecular weight. Biodegradable anastomotic tubes were prepared from these diblock copolymers using electrospinning technique. The thickness of anastomotic tube could be regulated by spinning conditions. Anastomotic tubes had exhibited excellent hemocompatibility (hemolysis ratios were ranged from 0.5% to 1.5%) and cytocompatibility. After 3 days, epithelial cells were adhered closely and covered fully on the surface of nanofibrous tubes. Moreover, mPEG-b-PLGA₃ based anastomotic tube had play an important role to improve the healing and reconstruction process of cecal incision. The biodegradable anastomotic tubes from diblock copolymers of mPEG-b-PLA and mPEG-b-PLGA could promote healing and reconstruction of digestive tract and might play an important role after operation.

Keywords:

• Anastomotic tube
• biodegradable
• diblock copolymer
• nanofibrous film

Acknowledgments

The authors acknowledge the financial support from the Zhejiang Provincial Natural Science Foundation of China (Grant No. LY15H160058), the National Natural Science Foundation of China (Grant No. 81572291), Zhejiang Provincial Medical technology science project (Grant No. 2015KYB245), Supported by Suzhou Key Medical Center (Grant No. LCZX201505), Chinese Natural Science Foundation (Grant No. 81672970), the Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project Funding (Grant No. 2015.07).