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Abstract
States of anxiety and fear are controlled in organism by GABA-ergic and serotonine- ergic systems. Concepts about the structure and functions of GABAA receptor channel, benzodiazepine and serotonine receptors have been considered. Structural and conformational peculiarities of ligands of these receptors determine their role (agonists, antagonists, inverse agonists, partial agonists, partial inverse agonists) at the formation of supramolecular complexes ‚ligand-receptor’ and, as a result, pharmacological effects of ligands.