Comparison between Roesy and ¹³C NMR Complexation Shifts in Deriving the Geometry of Inclusion Compounds: A Study on the Interaction between Hyodeoxycholic Acid and 2-Hydroxypropyl-β-Cyclodextrin

Adele Mucci Dipartimento di Chimica, Università di Modena e Reggio Emilia, Via Campi 183, I-41100, Modena, Italy

Luisa Schenetti Dipartimento di Chimica, Università di Modena e Reggio Emilia, Via Campi 183, I-41100, Modena, Italy

Maria A. Vandelli Dipartimento di Scienze Farmaceutiche, Università di Modena e Reggio Emilia, Via Campi 183, I-41100, Modena, Italy

Barbara Ruozi Dipartimento di Scienze Farmaceutiche, Università di Modena e Reggio Emilia, Via Campi 183, I-41100, Modena, Italy

Gianfranco Salvioli Dipartimento di Medicina, Università di Modena e Reggio Emilia, Viale Vittorio Veneto, 9, I-41100, Modena, Italy

Flavio Forni Dipartimento di Scienze Farmaceutiche, Università di Modena e Reggio Emilia, Via Campi 183, I-41100, Modena, Italy

Abstract

The formation and geometry of the hyodeoxycholic acid (HDCA)/2-hydroxypropyl-β-cyclodextrin (HPβCD) complex in methanol-d₄ solution was determined through a rotating frame nuclear Overhauser (ROESY) experiment. The reported results confirmed those independently and previously obtained though the use of ¹³C complexation shifts in the same solvent. The ¹³C approach, which needs shorter experimental times and is currently used in the study of HPβCD/bile acid systems, was then substantiated.

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Comparison between Roesy and ¹³C NMR Complexation Shifts in Deriving the Geometry of Inclusion Compounds: A Study on the Interaction between Hyodeoxycholic Acid and 2-Hydroxypropyl-β-Cyclodextrin

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Comparison between Roesy and 13C NMR Complexation Shifts in Deriving the Geometry of Inclusion Compounds: A Study on the Interaction between Hyodeoxycholic Acid and 2-Hydroxypropyl-β-Cyclodextrin

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Comparison between Roesy and ¹³C NMR Complexation Shifts in Deriving the Geometry of Inclusion Compounds: A Study on the Interaction between Hyodeoxycholic Acid and 2-Hydroxypropyl-β-Cyclodextrin