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Original Articles

Reaction of monensin silver salt with methyl iodide: smooth alkylation of a tightly hydrogen-bonded carboxylate

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Pages 19-21 | Received 28 May 2010, Accepted 28 Jun 2010, Published online: 27 Aug 2010
 

Abstract

Despite its structural similarity to the sparingly reactive sodium salt of monensin, the silver salt of monensin was smoothly alkylated with methyl iodide on the carboxyl group to give the methyl ester of monensin.

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