Abstract
The complexation of several local anaesthetics by β and γ-cyclodextrins was studied by potentiometry with glass electrode. Tetracaine and dibucaine complexation constants were determined at 25°C in the presence of 0.1 M of NaCl. It was found that prilocaine and lidocaine complexes cannot be detected.
Acknowledgements
Financial support from the Direccion General de Investigacion (Ministerio de Educacion y Ciencia) of Spain and FEDER (Project CTQ2005-07428/BQU) and from the Direccion General de Programas y Transferencia de Conocimiento (Ministerio de Ciencia e Innovacion) of Spain (Project CTQ2008-04429/BQU) is gratefully acknowledged.