Synthesis and DNA interaction of the novel mixed-ligand polymers that incorporate bis(2-benzimidazolylmethyl) sulfide

Abstract

Two novel DNA-intercalating binuclear polymers, [Co₂(nipa)(Hbims)₂] (1) and [Cu(nipa)(H₂O)]·10H₂O (2) with nipa and bims (H₂nipa = 5-nitroisophthalic acid, H₂bims = bis(2-benzimidazolylmethyl) sulfide), have been synthesised by hydrothermal methods and characterised by elemental analysis, IR, single-crystal X-ray diffraction, UV–vis and fluorescent spectrum. 5-Nitroisophthalate ligand adopts μ₂- and μ₄-bridging coordination fashion and bims exists as bridging-mode in complexes. The DNA-binding interactions and their in vitro cytotoxicities towards four selected tumour cell lines have been investigated. Both of them bind to DNA by intercalative mode, presenting the high DNA-binding affinity. They possess the highest inhibitory rate on A549 and show good inhibition activity.

Keywords:

• crystal structure
• bis(2-benzimidazolylmethyl) sulfide
• 5-Nitroisophthalic acid
• DNA interaction

Acknowledgement

We acknowledge financial support by the National Natural Science Foundation of China [grant number 51463023] and [grant number 21461028], Guangxi Key Laboratory of Farm Products Processing (Cultivation Base) and Guangxi Colleges and Universities Program of Innovative Research Team and Outstanding Talent.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China [grant number 51463023]; [grant number 21461028].