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Abstract
Vancomycin is currently used as last-line therapy against many Gram-positive bacterial pathogens. Herein, we report a series of peptidomimetic norbornene-based anion receptors that were designed as simple vancomycin mimics New hosts were evaluated for their affinity to both acetate and acetyl D-Ala by 1H NMR titration. Modest binding to both anions was observed in DMSO-d 6 (Log Ka 1–2 for TBA Acetyl D-Alanine) in the anticipated 1:1 mode of binding.
Supplemental data
Supplemental data for this article can be accessed here: http://dx.doi.org/10.1080/10610278.2015.1086764.
Acknowledgements
The authors would like to thank Professors Roger Nation and Jian Li for assistance with the disk diffusion assay and Dr Deni Taleski for his insight.
Notes
1. While the modified Job Plots did not contibute reliable data for assesment of binding stoiciometry, in this study, they are included in the supplemental data for full disclosure of results.
