Selectivity/structure correlation in cyclodextrin chemistry

Abstract

Generally we can not fit a “guest” to a cyclodextrin (CD), but we can select (or even synthesize by modifying the CD-structure) a better fitting -host-for a given pest. For the majority of potential guests (the most appropriate) CD-(derivative) and the most adequate conditions can be found, which make it possible to distinguish the hosvguest complex from other components in a multi-component system. This distinction wiil then be embodied in the separation of a given guest (by chromatography, extraction, selective precipitation, etc.), in selective reactions (regio- and enantiose- lective reactions, catalytic effects, etc.), in specific biological re- sponses (accelerated and improved absorption, toxicity or elimination of toxic effects, etc.), in selective modification of physical-chemical parameters (spectral characteristics, dissociation, electrochemical properties, etc.). Recent examples for such selective interactions and their practical utilizations in technologies and industrial products illustrate the significance of structudselectivity correlation in the CD-chemistry.