Design of New Host Compounds, 1,3-diphenyl-cyclohexane-1,3-diol, 1,4-, 1,3- and 1,2-bis(hydroxydiphenylmethyl)cyclohexanes, and 1,2-bis(hydroxydiphenylmethyl)cyclopropane

Abstract

The title host compounds were designed. The cis-1,3-diphenylcyclohexane-1,3-diol, its 2-methyl derivative, as well as the cis- and trans-isomers of 1,4- and 1,3-bis(hydroxydiphenylmethyl)cyclohexanes showed high inclusion ability for guest compounds. However, while the trans-1,2-bis(hydroxydiphenylmethyl)-cyclopropane showed also a good inclusion ability, cis-1,2-bis(hydroxydiphenylmethyl)cyclohexane showed none. In order to evaluate the structural features which control the inclusion behavior of the newly designed host compounds, molecular and crystal structures of inclusion complexes of trans-1,4-bis(hydroxydiphenylmethyl)cyclohexane with acetone and with MeOH, and of cis-1,3-diphenylcyclohexane-1,3-diol with EtOH were determined.