Abstract
N-Methyldeoxycholamide (1) was recrystallized from over one hundred organic substances in a search for inclusion compounds. Only ethylene glycol (EG) was included into host assemblies together with water. Other solvents gave hemihydrate crystals without organic guests. X-ray structural analysis revealed that the former inclusion crystal has a three-leaved building block similar to that of glycodeoxycholic acid (2). Tomographical analysis of both the assemblies gave an insight about such an extremely specific inclusion behavior from the viewpoint of steric and hydrogen-bonding terms.