Chemotherapeutic Targeting of Etoposide to Regions of the Brain on the Basis of Polyamine Level

Satoru Watanabe Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan

Shoichi Sato Department of Medical Technology, Kawasaki College of Allied Health Professions, 316 Matsushima, Kurashiki City, Okayama 701-0194, Japan

Sumika Nagase Department of Medical Technology, Kawasaki College of Allied Health Professions, 316 Matsushima, Kurashiki City, Okayama 701-0194, Japan

Kazuaki Shimosato Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan

Seitaro Ohkuma Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan

Abstract

The effects of etoposide on body weight, regional weights, and the concentrations of putrescine, spermidine and spermine in the cerebellum, hippocampus, corpus striatum, cortex, the combined regions of the thalamus and hypothalamus and the diencephalon of the brain were examined in rats. Etoposide seems to be a better choice for management of cortical and hippocampal tumors because it reduces polyamines, which are associated with tumor cell growth, but not for the management of tumors of the diencephalon and corpus striatum because it increases polyamines.

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Chemotherapeutic Targeting of Etoposide to Regions of the Brain on the Basis of Polyamine Level

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Chemotherapeutic Targeting of Etoposide to Regions of the Brain on the Basis of Polyamine Level

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