Matrix metalloproteases: Underutilized targets for drug delivery

Abstract

Pathophysiological molecules in the extracellular environment offer excellent targets that can be exploited for designing drug targeting systems. Matrix metalloproteases (MMPs) are a family of extracellular proteolytic enzymes that are characterized by their overexpression or overactivity in several pathologies. Over the last two decades, the MMP literature reveals heightened interest in the research involving MMP biology, pathology and targeting. This review describes various strategies that have been designed to utilize MMPs for targeting therapeutic entities. Key factors that need to be considered in the successful design of such systems have been identified based on the analyses of these strategies. Development of targeted drug delivery using MMPs has been steadily pursued; however, drug delivery efforts using these targets need to be intensified and focused to realize the clinical application of the fast developing fundamental MMP research.

Keywords: :

• Drug delivery
• drug targeting
• matrix metalloprotease (MMP)
• prodrug
• drug activation

Acknowledgements

Our original work in MMP-based drug targeting has been funded by the National Eye Institute (EY014357) and was conducted in facilities constructed with support from Research Facilities Improvement Program Grant Number C06 RR15482 from the National Center for Research Resources, NIH. The authors thank Ernie Gemeinhart for careful proofreading and critical review of this manuscript.