Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy

Abstract

In recent years, there have been many exciting developments in the biomedical applications of the macrophage membrane bionic drug delivery system (MM-Bio-DDS). Macrophages, as an important immune cell, are involved in initiating and regulating the specific immune response of the body. Therefore, the inflammatory process related to macrophages is an important goal in the diagnosis and treatment of many diseases. In this review, we first summarise the different methods of preparation, characterisation, release profiles and natural advantages of using macrophages as a drug delivery system (DDS). Second, we introduce the processes of various chronic inflammatory diseases and the role of macrophages in them, specifically clarifying how the MM-Bio-DDS provides a wide and effective treatment for the targeted inflammatory site. Finally, based on the existing research, we propose the application prospect and existing challenges of the MM-Bio-DDS, especially the problems in clinical transformation, to provide new ideas for the development and utilisation of the MM-Bio-DDS in targeted drug delivery for inflammation and the treatment of diseases.

Keywords:

• Macrophage
• macrophage membrane
• biomimetic drug delivery systems
• inflammation targeting
• inflammation-related diseases

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research was supported by the State Administration of Traditional Chinese Medicine of the People's Republic of China (CN) [Grant Number: T20194828003], the Xinglin Scholar Discipline Promotion Talent Program of Chengdu University of Traditional Chinese Medicine [Grant Number: QNXZ2018018], the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine [Grant Number: TCM-201908]