Hazard Rate Regression Using Ordinary Nonparametric Regression Smoothers

Abstract

This article proposes a method for nonparametric estimation of hazard rates as a function of time and possibly multiple covariates. The method is based on dividing the time axis into intervals, and calculating number of event and follow-up time contributions from the different intervals. The number of event and follow-up time data are then separately smoothed on time and the covariates, and the hazard rate estimators obtained by taking the ratio. Pointwise consistency and asymptotic normality are shown for the hazard rate estimators for a certain class of smoothers, which includes some standard approaches to locally weighted regression and kernel regression. It is shown through simulation that a variance estimator based on this asymptotic distribution is reasonably reliable in practice. The problem of how to select the smoothing parameter is considered, but a satisfactory resolution to this problem has not been identified. The method is illustrated using data from several breast cancer clinical trials.

Key Words:

• Censored data
• Kernel regression
• Locally weighted linear regression
• Survival analysis