Multivariate Analysis of the First 10 MEIC Chemicals

Abstract

Nonlinear mapping coupled to powerful graphical tools was used to compare the texicological responses of 32 in vivo and in vitro test systems to the first 10 MEIC chemicals. The obtained results clearly underline the usefulness of our methodological approach for the comparison of the different endpoints and the selection of a battery of in vitro toxicity tests allowing to estimate the possible harmful effects of chemicals in vivo.

Key Words:

• in vivo toxicity
• in vitro toxicity
• MEIC chemical
• multivariate analysis
• nonlinear mapping
• graphical analysis