Hazard Evaluation Support System (HESS) for predicting repeated dose toxicity using toxicological categories

Abstract

Repeated dose toxicity (RDT) is one of the most important hazard endpoints in the risk assessment of chemicals. However, due to the complexity of the endpoints associated with whole body assessment, it is difficult to build up a mechanistically transparent structure–activity model. The category approach, based on mechanism information, is considered to be an effective approach for data gap filling for RDT by read-across. Therefore, a library of toxicological categories was developed using experimental RDT data for 500 chemicals and mechanistic knowledge of the effects of these chemicals on different organs. As a result, 33 categories were defined for 14 types of toxicity, such as hepatotoxicity, hemolytic anemia, etc. This category library was then incorporated in the Hazard Evaluation Support System (HESS) integrated computational platform to provide mechanistically reasonable predictions of RDT values for untested chemicals. This article describes the establishment of a category library and the associated HESS functions used to facilitate the mechanistically reasonable grouping of chemicals and their subsequent read-across.

Keywords:

• repeated dose toxicity
• category approach
• read-across
• hazard evaluation support system
• halobenzenes

Acknowledgements

This work was supported by a New Energy and Industrial Technology Development Organization (NEDO) and a Ministry of Economy, Trade and Industry (METI) grant for the ‘Development of Hazard Assessment Technology Using Structure-activity Methods’.

Notes

Presented at the 15th International Workshop on Quantitative Structure–Activity Relationships in Environmental and Health Sciences (QSAR2012), 18–22 June 2012, Tallinn, Estonia.