Effect of Repeated Application of C₆₀ Combined with UVA Radiation Onto Hairless Mouse Back Skin

Takeshi Moriguchi Department of Chemistry, Saitama Medical School, 981 Kawakado, Moroyama-machi, Iruma-gun, Saitama, 350-0496, Japan

Kazuyuki Yano Department of Chemistry, Saitama Medical School, 981 Kawakado, Moroyama-machi, Iruma-gun, Saitama, 350-0496, Japan

Shigeru Hokari First Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan

Masaru Sonoda Department of Food and Nutrition, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda-ku, Tokyo, 101-8433, Japan

Abstract

Repeated application of buckminsterfullerene (C₆₀) toluene solution combined with ultraviolet A (UVA) radiation onto hairless mouse back skin resulted in enhancing formation of erythema as an acute disease but induced no carcinoma on the skin. This result is probably due to insolubility of C₆₀ in the living cells to generate little singlet oxygen ¹O₂ by UVA radiation.

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Effect of Repeated Application of C₆₀ Combined with UVA Radiation Onto Hairless Mouse Back Skin

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Effect of Repeated Application of C₆₀ Combined with UVA Radiation Onto Hairless Mouse Back Skin