Analysis of C-850T and G-308A Polymorphisms of the Tumor Necrosis Factor-α Gene in Maya-Mestizo Women with Preeclampsia

Abstract

Objective: To determine whether polymorphisms in the TNF-α promoter gene are associated with preeclampsia. Methods: 105 women with preeclampsia and 200 controls were genotyped for the G-308A and C-850T polymorphisms by RFLP. Differences in allele, genotype, and haplotype frequencies between groups were assessed. Results: The genotypic and allelic distribution of both polymorphisms was similar between groups. Moreover, the estimated overall pair of loci haplotype frequencies did not differ significantly. Conclusion: We did not find any association between these polymorphisms and the risk for preeclampsia. However, we found that both the genotypic and allelic distribution in our population differed from those reported in other populations.

Keywords:

• C-850T polymorphism
• G-308A polymorphism
• Maya-Mestizo women
• Promoter of the TNF-α
• Preeclampsia