Perinatal Changes of Circulating N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in Normal and Intrauterine-Growth-Restricted Pregnancies

Nicoletta Iacovidou Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece

, MD,

Despina D. Briana Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece

, MD,

Maria Boutsikou Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece

, MD,

Demetrios Gourgiotis Research Laboratories, Second Department of Paediatrics, Athens University Medical School, Athens, Greece

, PhD,

Stavroula Baka Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece

, MD,

Venetia-Maria Vraila Research Laboratories, Second Department of Paediatrics, Athens University Medical School, Athens, Greece

, MD,

Demetrios Hassiakos Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece

, MD &

Ariadne Malamitsi-Puchner Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, GreeceCorrespondence[email protected] [email protected]

, MD show all

Abstract

Objective: To investigate changes in NT-proBNP in intrauterine-growth-restricted (IUGR) and appropriate-for-gestational-age (AGA) pregnancies. Methods: NT-proBNP levels were measured in 40 mothers (MS), umbilical cords (UC), and their 20 IUGR/ 20 AGA neonates on day 1 (N1) and day 4 (N4). Results: UC, N1, and N4 NT-proBNP was lower in IUGR pregnancies (p ≤ 0.049). In both groups, NT-proBNP levels were similar in MS and higher in N1 (p ≤ 0.001). In AGA, MS NT-proBNP correlated positively with UC. Conclusions: Fetal and neonatal NT-proBNP levels are lower in IUGR compared with AGA, probably due to blood flow redistribution in IUGR and NT-proBNP placental transport in AGA. NT-proBNP levels peak on N1.

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Perinatal Changes of Circulating N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in Normal and Intrauterine-Growth-Restricted Pregnancies

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Perinatal Changes of Circulating N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in Normal and Intrauterine-Growth-Restricted Pregnancies

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