Genetic Thrombophilia Variants and Risk for Preeclampsia Among American Indians

Abstract

Objective: To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia. Methods: A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms. Results: The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found. Conclusion: The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.

Keywords:

• Pre-eclampsia
• Genetics
• Factor V Leiden
• Prothrombin 20210 polymorphism
• American Indian

Notes

Supported by NIH Grant Number P20 RR016741 from the INBRE Program of the Nation Center for Research Resources.