Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk

ABSTRACT

Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. Results: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. Conclusions: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.

KEYWORDS:

• Angiotensin receptor 2
• pregnancy induced hypertension
• single nucleotide polymorphisms
• haplotype analysis

Acknowledgments

The authors gratefully acknowledge the support of Yichang Maternal and Child Care hospital, Anyang Maternal and Child Care Hospital and the National Natural Science Foundation of China.

Declaration of interest

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [81172679/H2605].