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ABSTRACT
Objectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene.
Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis.
Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed.
Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GTn polymorphism.
Acknowledgments
We would like to thank HelioKushima for performing the HO-1 ELISA and the staff at the Laboratory of Molecular Neuroendocrinology (Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil), coordinated by Margaret de Castro, MD, PhD, for their technical support in the GTn polymorphism analysis.
Data availability statement
The data that support the findings of this study are available from the corresponding author, VCS, upon reasonable request.
Disclosure statement
No potential conflict of interest was reported by the authors.