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Maternal asthma and the risk of hypertensive disorders of pregnancy: a systematic review and meta-analysis of cohort studies

, , , , , , , , & show all
Pages 12-24 | Received 22 Feb 2019, Accepted 11 Nov 2019, Published online: 25 Nov 2019
 

ABSTRACT

Objective: The aim of this study was to demonstrate the association between maternal asthma and the risk of hypertensive disorders of pregnancy.

Methods: A systematic search of seven databases was conducted. A meta-analysis was performed to calculate risk ratios and 95% CI using random-effects models.

Results: Asthma was associated with an increased risk of pregnancy-induced hypertension (RR 1.45, 95%CI 1.29–1.63), transient hypertension of pregnancy (RR 2.00, 95%CI 1.52–2.63), preeclampsia or eclampsia (RR 1.28, 95%CI 1.25–1.32), preeclampsia (RR 1.43, 95%CI 1.31–1.57) and eclampsia (RR 1.56, 95%CI 1.13–2.15).

Conclusion: The meta-analysis illustrated that asthma was significantly increased risk of hypertension during pregnancy.

Author’s contribution

WM: Project development, data collection, data analysis, manuscript writing/editing. HB, LX: Data collection, data analysis. LY, JL: Data check, data analysis. WB, WH, LD: manuscript examination. YH, QJ: Project development, manuscript editing.

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary Material

Supplemental data for this article can be accessed here.

Additional information

Funding

This study was not funded.

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