Plasma concentrations of tissue kallikrein in normal and preeclamptic pregnancies

ABSTRACT

Objective: To investigate maternal plasma concentrations of tissue kallikrein (TK) in normal and preeclamptic pregnancies.

Methods: 96 women with singleton pregnancies were categorized into normal, mild preeclampsia and preeclampsia with severe features. Plasma levels of TK were quantified by ELISA and left lateralrecumbencyposition BP measured.

Results: Maternal plasma TK concentrations were significantly lower in preeclampsia with severe features compared with mild preeclampsia and normal pregnant. Plasma TK concentrations were negatively correlated with systolic and diastolic blood pressure, and 24-hour urine protein.

Conclusion: Lower maternal plasma TK may be a risk marker that reflects the severity of preeclampsia.

KEYWORDS:

• Preeclamptic
• tissue kallikrein
• pregnancy
• blood pressure

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

We would like to acknowledge grant support for our laboratory from the National Natural Science Foundation of China (81770452, 81470401). Maternal and Jiangsu Provincial Maternal and child health research project of JiangSu Health Department, China (F201546).