Maternal serum perlecan levels in women with preeclampsia

ABSTRACT

Objective: Perlecan is an extracellular matrix proteoglycan suggested to maintain endothelial functions. We aimed to measure maternal serum perlecan levels in different preeclampsia phenotypes.

Methods: This study included 50 women with preeclampsia and 30 healthy pregnant women.

Results: Serum perlecan levels were significantly higher (p = 0.016) in preeclamptic women with severe features(n = 23) than preeclampsia patients(n = 27). There were no statistically significant differences in serum perlecan levels between the early-onset preeclampsia(n = 25), late-onset preeclampsia(n = 25), and healthy pregnancies.

Conclusion: Our findings suggest that preeclamptic women with severe features have higher serum perlecan levels than women with preeclampsia.

KEYWORDS:

• Preeclampsia
• perlecan
• severe preeclampsia

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the Manisa Celal Bayar University Coordinatorship of Scientific Research Projects  [Grant no. 2019-070].