ABSTRACT
Objective
This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis.
Methods
ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen).
Results
The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia.
Conclusion
These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.
KEYWORDS:
Author contributions
Jianbo Wu conceived the project and designed the experiments. Yanyan Xu conducted experiments and wrote the manuscript. Junjiao Wu revised the manuscript.
Competing interests
The authors declare no competing financial interests.