Serum apelin and galectin-3 in preeclampsia in Iraq

ABSTRACT

Objective

This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE).

Methods

Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant.

Results

The PE group had significantly lower apelin and higher galectin-3 levels than the control group. PE group exhibited dyslipidemia and had higher β-cell functions than the controls. Galectin-3 level correlates with insulin, glucose, and IR. High galectin-3 also is correlated positively with dyslipidemia.

Conclusion

In PE, there is a possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia.

KEYWORDS:

• Apelin
• galectin-3
• preeclampsia
• insulin resistance
• lipid profile

Acknowledgments

We are grateful to the University of Kashan for supporting this work.

Disclosure statement

The authors have no conflict of interest with any commercial or other association in connection with the submitted article.

Additional information

Funding

There was no specific funding for this specific study.