Predictive value of early second trimester maternal serum cyclophilin A concentrations in women complicated with preeclampsia: a preliminary case–control study

ABSTRACT

Objective

To investigate cyclophilin A in early second trimester of pregnancy before the onset of preeclampsia.

Methods

In this prospective case-control study, 51 pregnant women whose serum were collected and stored and who developed preeclampsia in later follow-up and 41 pregnant women as control group were included.

Results

Maternal serum cyclophilin A levels in the study group who developed preeclampsia in later follow-up were significantly higher than those of normal healthy pregnant women.

Conclusion

Cyclophilin A may be a valuable predictor for pregnant women who subsequently develop preeclampsia in their pregnancies.

KEYWORDS:

• Pregnancy
• gestational hypertension
• preeclampsia
• cyclophilin A
• predictive models

Data availability statement

All relevant clinical and biological data are available within the article, or available from the authors upon a reasonable request.

Disclosure statement

All the authors declare there are no potential conflicts of interest exist with respect to the research, authorship, and/or publication of this article.

Additional information

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.