Prognostic role of increased serum homocysteine concentration in preeclampsia

ABSTRACT

Objective: To assess homocysteine (Hcy) concentration in women with preeclampsia (PE).

Methods: Hcy concentrations were detected by ELISA in 305 pregnancies.

Results: Hcy concentration in patients with PE was 16.07 umol/L at 10–14 weeks as compared to 7.19 umol/L in normotensive pregnancies (p < 0.0001). Optimal cutoff level for Hcy in the first trimester of pregnancy was >9.55 umol/L with area under curve of 0.859, sensitivity of 91.67%, specificity of 72.24%.

Conclusion: Assessment of serum Hcy concentration may be used as a predictor of PE, with the highest diagnostic utility in the first trimester of pregnancy.

KEYWORDS:

• Preeclampsia
• prediction of preeclampsia
• serum homocysteine
• hypertension in pregnancy
• hypertensive disorders

Acknowledgments

The authors are grateful to West Kazakhstan Marat Ospanov Medical University.

Disclosure statement

No competing financial interests exist.

Author Contributions

All authors had full access to all the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Akylbek Tussupkaliyev, Andrey Gaiday, Saule Bermagambetova, Svetlana Sakhanova

Acquisition of data: Akylbek Tussupkaliyev, Andrey Gaiday, Saule Bermagambetova

Statistical analyses and data interpretation: Akylbek Tussupkaliyev, Andrey Gaiday, Andrii Dinets

Drafting of the manuscript: Andrey Gaiday, Andrii Dinets.

Obtained funding: Akylbek Tussupkaliyev, Andrey Gaiday, Saule Bermagambetova, Svetlana Sakhanova

Study supervision: Akylbek Tussupkaliyev, Andrii Dinets.

Additional information

Funding

This work was part of the program “Development of new technologies for child health and reproductive health” from the Ministry of Health and Social Development of the Republic of Kazakhstan under the grant 0114RКI00485.