ABSTRACT
Objective: To assess homocysteine (Hcy) concentration in women with preeclampsia (PE).
Methods: Hcy concentrations were detected by ELISA in 305 pregnancies.
Results: Hcy concentration in patients with PE was 16.07 umol/L at 10–14 weeks as compared to 7.19 umol/L in normotensive pregnancies (p < 0.0001). Optimal cutoff level for Hcy in the first trimester of pregnancy was >9.55 umol/L with area under curve of 0.859, sensitivity of 91.67%, specificity of 72.24%.
Conclusion: Assessment of serum Hcy concentration may be used as a predictor of PE, with the highest diagnostic utility in the first trimester of pregnancy.
Acknowledgments
The authors are grateful to West Kazakhstan Marat Ospanov Medical University.
Disclosure statement
No competing financial interests exist.
Author Contributions
All authors had full access to all the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Akylbek Tussupkaliyev, Andrey Gaiday, Saule Bermagambetova, Svetlana Sakhanova
Acquisition of data: Akylbek Tussupkaliyev, Andrey Gaiday, Saule Bermagambetova
Statistical analyses and data interpretation: Akylbek Tussupkaliyev, Andrey Gaiday, Andrii Dinets
Drafting of the manuscript: Andrey Gaiday, Andrii Dinets.
Obtained funding: Akylbek Tussupkaliyev, Andrey Gaiday, Saule Bermagambetova, Svetlana Sakhanova
Study supervision: Akylbek Tussupkaliyev, Andrii Dinets.