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Research Article

Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study

Petar Cabunaca Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, SerbiaCorrespondence[email protected]

Nataša Karadžov Orlića Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia;b Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Daniela Ardalićc Department of Medical Biochemistry, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia

Barbara Damnjanović Pažina Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia

Srđan Stanimirovića Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia

Gorica Banjacc Department of Medical Biochemistry, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia

Aleksandra Stefanovićd Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

Vesna Spasojević- Kalimanovskad Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

Amira Egića Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia;b Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Nina Rajovićb Faculty of Medicine, University of Belgrade, Belgrade, Serbia;c Department of Medical Biochemistry, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia

Nataša Miliće Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia;f Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA

Željko Mikovića Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia;b Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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ABSTRACT

OBJECTIVE: This study aimed to assess the accuracy of The Fetal Medicine Foundation (FMF) screening algorithm for the prediction of preeclampsia.

METHODS: Out of 138 women with high-risk pregnancies prospectively followed, 30 developed preeclampsia. The clinical examination and biochemical measurements were performed at first, second, early and late third trimester.

RESULTS: A lower PAPP-A levels were found in the first trimester, while sFlt/PlGF was increased in the second and early third trimester in preeclampsia (p>0.05). FMF algorithm presented higher specificity (>70%), but had a drawback of lower sensitivity (35–77%).

CONCLUSION: FMF algorithm had modest performance in the prediction of preeclampsia for high-risk pregnancies.

KEYWORDS:

Disclosure statement

No potential conflict of interest was reported by the authors.

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Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study

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Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study

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