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Research Article

Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis

ORCID Icon, , &
Pages 180-185 | Received 23 Dec 2020, Accepted 20 Apr 2021, Published online: 17 May 2021
 

ABSTRACT

Objective: We investigated, via systematic review and meta-analysis, whether multiple sclerosis (MS) is associated with the risk of preeclampsia (PE).

Methods: From the eligible studies, we pooled odds ratios (ORs) and confidence intervals (CIs) of PE for pregnant women with MS compared with pregnant women without it using the fixed-effects model. The I2 measured heterogeneity between studies.

Results: Eight eligible studies (9 cohorts) were included. Pregnant women with MS had no excess risk of PE compared with pregnant women without MS (pooled OR = 0.99, 95% CI: 0.89, 1.09; I2 = 0.00%).

Conclusion: MS is not associated with PE.

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary material

Supplemental data for this article can be accessed here

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