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Hypertension in Pregnancy Volume 40, 2021 - Issue 3
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Research Article

Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital

Mehmet Akif Erdola Department of Cardiology, Turkish Ministry of Health, Ankara City Hospital, Ankara, TurkeyORCID Iconhttps://orcid.org/0000-0002-2721-440XView further author information
ORCID Icon,
Atakan Tanacanb Department of Obstetrics and Gynecology, Turkish Ministry of Health, Ankara City Hospital, Ankara, TurkeyORCID Iconhttps://orcid.org/0000-0001-8209-8248View further author information
ORCID Icon,
Hasan Erogluc Department of Obstetrics and Gynecology, Turkish Ministry of Health, Gazi Antep Training and Research Hospital, Gazi Antep, TurkeyORCID Iconhttps://orcid.org/0000-0002-1180-5299View further author information
ORCID Icon,
Nazan Vanli Tonyalid Department of Obstetrics and Gynecology, Turkish Ministry of Health, Etlik Zubeyde Hanim Women’s Health Training and Research Hospital, Ankara, TurkeyORCID Iconhttps://orcid.org/0000-0002-7284-6887View further author information
ORCID Icon,
Mehmet Erdogane Department of Cardiology, Yildirim Beyazid University, Ankara City Hospital, Ankara, TurkeyView further author information
,
Aykan Yucelf Department of Obstetrics and Gynecology, University of Health Sciences, Turkish Ministry of Health, Ankara City Hospital, Ankara, TurkeyORCID Iconhttps://orcid.org/0000-0002-5888-692XView further author information
ORCID Icon,
Nuray Yazihang Department of Pathophysiology, Ankara University, Faculty of Medicine, Internal Medicine, Pathophysiology Department, Ankara University, Institute of Health Sciences, Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara, TurkeyORCID Iconhttps://orcid.org/0000-0003-1237-8468View further author information
ORCID Icon &
Dilek Sahinf Department of Obstetrics and Gynecology, University of Health Sciences, Turkish Ministry of Health, Ankara City Hospital, Ankara, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8567-9048View further author information
ORCID Icon show all
Pages 202-208 | Received 16 Nov 2020, Accepted 02 Jun 2021, Published online: 18 Jun 2021
 
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ABSTRACT

Background: This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT).

Method: 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated.

Results: NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04).

Conclusion: NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.

Disclosure of potential conflicts of interest

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was funded by Etlik Zubeyde Hanim Women's Health Training and Research Hospital (project number:2020/016).

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