Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia

ABSTRACT

Objective: To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE).

Methods: The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32.

Results: Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients. Conclusion: Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.

KEYWORDS:

• Gene polymorphism
• il-32
• preeclampsia
• pregnancy

Acknowledgments

We would like to thank Professor Abbas Aflatoonian, the head of Yazd Reproductive Sciences Institute for his scientific recommendations.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Shahid Sadoughi University of Medical Sciences provided the grant for this research project. This manuscript is a part of the M.Sc thesis of Fatemeh Mazlum.