ABSTRACT
Background and Purpose
MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown.
Methods
The human placental microvascular endothelial cells (HPMECs) have undergone hypoxia and reoxygenation (H/R) treatment to establish PIH cellular model. Rats were performed with reduced uterine perfusion pressure (RUPP) operation to establish PIH animal model.
Results
MiR-125b-5p promoted viability while inhibited the apoptosis of H/R-treated HPMECs by downregulating BMF. MiR-125b-5p alleviated hypertensive symptoms and improved pregnancy outcomes in RUPP rats.
Conclusion
MiR-125b-5p ameliorates H/R-induced HPMEC dysfunction and attenuates RUPP-induced hypertension in pregnant rats by downregulating BMF.
Acknowledgments
Not applicable.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Consent for publication
Not applicable.
Ethics approval and consent to participate
All institutional and national guidelines for the care and use of laboratory animals were followed.
Data availability statement
The data underlying this article will be shared on reasonable request to the corresponding author.