Salt Sensitivity, Anxiety, and Irritability Predict Blood Pressure Increase over Five Years inHealthy Males

Abstract

Salt sensitivity and psychological factors are thought to be associated with a higher risk for the development of hypertension but data on the relation between age-related blood pressure increase and salt sensitivity or psychological factors are scarce. A total of 31 healthy young males who were previously classified with respect to salt sensitivity, mental stress reactivity, trait-anxiety, trait-anger, and irritability were followed up 4.8 years later by 24 hr ambulatory blood pressure monitoring (ABP). Our results showed anxiety and irritability correlated significantly with 24-hr ABP 4.8 years later (p < 0.05). The increase of diastolic blood pressure over 4.8 years was higher in salt-sensitive than salt-resistant subjects (p < 0.07). Heart rate and diastolic blood pressure correlated significantly with systolic and diastolic 24-hr ABP and blood pressure reactivity under mental stress with diastolic 24-hr ABP. A regression analysis that included cardiovascular and psychological factors yielded 34% (systolic ABP, p < 0.009) and 58% (diastolic ABP, p < 0.0001) of variance. We concluded that anxiety and irritability are important predictors of blood pressure increase over time in healthy males.

Keywords:

• anxiety
• blood pressure
• irritability
• mental stress reactivity
• salt sensitivity

Notes

21. Spielberger CD, Gorsuch RL, Lushene RE, Laux L. STAI. In Internationale Skalen für Psychiatrie hrsg. vom Collegium Internationale Psychiatriae Scalarum. 4. überarbeitete und erweiterte Auflage. Beltz-Test, Göttingen, 1996; 27–30.

22. Fahrenberg J, Hampel R, Selg H. Das Freiburger Persönlichkeitsinventar FPI—Handanweisung. In 4. Auflage. Göttingen, Toronto, Zürich, Hogrefe. 1984.