Association between duration of excessive weight and arterial stiffness in middle-aged and older adults

ABSTRACT

This study aims to evaluate the association between duration of overweight/obesity and arterial stiffness. In total, 103 men and women aged 45–68 years with a body mass index (BMI) of ≥25 kg/m² were enrolled in this study. Duration of overweight/obesity was calculated for individuals with at least two consecutive BMI occurrences of ≥25 kg/m² in the previous (5-year intervals from 20 years old) and present BMI information. Multiple regression analysis showed that carotid-femoral pulse wave velocity, an index of arterial stiffness, was independently associated with the duration of overweight/obesity, but not with current degree of overweight/obesity.

KEYWORDS:

• Obesity period
• aortic stiffness
• cardiovascular risk

Acknowledgments

We thank Mr. Kaname Tagawa for his constructive advice. We are grateful to Dr. Keisei Kosaki, Ms. Jiyeon Park, Mr. Hibiki Kawatani, Ms. Marina Fukuie, and Mr. Atsumu Yokota for technical assistance and helpful discussions. We would also like to thank the research members of K.T.’s laboratory and Tsuchiura City Health Promotion Section for their assistance in collecting the data.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.