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ABSTRACT
In this study, we revealed that melanin biomaterial extracted from squid ink-sacs could effectively remove both gram-positive and gram-negative bacteria from water. A solid/liquid ratio of 25 mg/mL, melanin was able to remove 82% and 63% of E. coli and V. vulcificus, respectively; and, at any tested solid/liquid ratios of 5, 15, or 25 mg/mL, melanin could eliminate almost all B.cereus and S.aureus. FTIR analysis showed differences in chemical properties on surfaces of melanin in cases of with and without bacterial adsorptions. Besides, melanin nanoparticle (200 nm in size) at a concentration of 2 mg/mL had an antibacterial activity with antibacterial diameters of 17, 15, 12 and 14 for E.coli, V. vulfinicus, S. aureus and B.cereus, respectively. More interestingly, melanin nanoparticles could enhance killing ability of X-ray on SKMEL28 cell about 20%. Conlusively, we suggested that melanin biomaterial could be applied in different fields in biology depending on its existing forms.
Acknowledgments
Nguyen Thi Le Na was supported by the PhD Scholarship Programme of Vingroup Innovation Foundation to participate in this research, code: VINIF.2019.TS.40
Disclosure statement
No potential conflict of interest was reported by the authors.