ABSTRACT
This study reports development of engineered fluorcanasite frankemenite-fluorapatite glass-ceramic materials for potential bone scaffold applications. A systematic approach was undertaken to selectively tune the glass compositions and process parameters towards developing bone mimicking crystalline microstructure and enhancement of bioactive response. Differential thermal analysis was performed to design a controlled two stage heat treatment profile to convert the synthesized glass compositions into glass-ceramics. X-ray diffraction studies confirmed the presence of fluorcanasite, frankamenite and fluorapatite as the predominant phases, where fluorapatite is anticipated to induce enhanced bioactivity. Scanning electron microscopy of the fractured glass-ceramics revealed interpenetrating lath like microstructure, responsible for mechanical interlocking of crystalline phases. Systematic pH study of the glass-ceramic candidates carried out in simulated body fluid (SBF) recorded initial increase followed by stable pH values, confirming bioactivity and minimal leaching. The results from our study therefore, establishes the promising potential of the novel glass-ceramic biomaterials.
Acknowledgments
The authors would like to acknowledge science and engineering research board-department of science and technology (SERB-DST) for supporting this project through extramural research grant (EMR/2016/007981). The authors also acknowledge Golcha Associated, MNIT Jaipur, CSIR-CGCRI Lab Kolkata and BITS-Pilani for providing the characterisation facilities.
Disclosure statement
No potential conflict of interest was reported by the authors.