Facile green synthesis of silver nanoparticles from sprouted Zingiberaceae species: Spectral characterisation and its potential biological applications

ABSTRACT

Zingiberaceae species are widely in traditional medicine throughout the world. This study evaluates the potential biological applications of phyto-functionalised silver nanoparticles (AgNPs) synthesised using sprouted Zingiberaceae species. The AgNPs were characterised and found to be spherical in the size of 25 nm-30 nm. The experimental results indicated that AgNPs have notable bactericidal activity against gram-positive and gram-negative bacteria. Human colon cancer cells (HCT15) were used to perform the anticancer assay and cell viability at a concentration of 500 µg/mL ranged from 43.71% to 49.49%. Also sprouted C. amada AgNPs at a concentration of 200 μg/mL provided maximum inhibition of 65.40% and 68.78% for α-amylase and α-glucosidase activity respectively. Furthermore, the sprouted Z. officinale AgNPs at a concentration of 500 µg/mL displayed significant glucose uptake percentage (99.56%) under in vitro conditions. The results indicated that phyto-functionalised AgNPs from sprouted Z. officinale and C. amada possess antibacterial, anticancer and antidiabetic activity.

KEYWORDS:

• Zingiberaceae
• sprouted species
• silver nanoparticle
• anticancer
• antidiabetic

Acknowledgments

The authors acknowledge the fellowship provided by Indian Council of Medical Research, New Delhi. The Senior Research Fellowship awarded to the research scholar Mr. S. M. Sathak Sameer, vide Fellowship No. 45/45/2018/MP/BMS

Compliance with Ethical Standards

No potential conflict of interest was reported by the authors.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Indian Council of Medical Research [45/45/2018/MP/BMS/].