Structural Damage Induced by Peroxidation May Account for Functional Impairment of Heavy Synaptic Mitochondria

Maurizio Battino Faculty of Medicine, Institute of Biochemistry, University of Ancona, Ancona, Via Ranieri 65, 60100 Ancona, Italy

Maria S. Ferreiro Department of Periodontology, School of Dentistry, University of Sevilla, Sevilla, Spain

GianPaolo Littarru Faculty of Medicine, Institute of Biochemistry, University of Ancona, Ancona, Via Ranieri 65, 60100 Ancona, Italy

José L. Quiles Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain

M.Carmen RamÍrez-Tortosa Department of Biochemistry, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain

Jesús R. Huertas Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain

José Mataix Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain

Roberto F. Villa Department of Physiological-Pharmacological Cellular-Molecular Sciences, Division of Pharmacology and Pharmacological Biotechnologies, University of Pavia, Pavia, Italy

Antonella Gorini Department of Physiological-Pharmacological Cellular-Molecular Sciences, Division of Pharmacology and Pharmacological Biotechnologies, University of Pavia, Pavia, Italy

show all

Abstract

Coenzyme Q distribution, as well as respiratory chain features, in rat brain mitochondria depend on mitochondrial subpopulation, brain region and age. Heavy mitochondria (HM) usually display the lowest content of respiratory components and the lowest enzymatic activities and it has been suggested that they represent the oldest mitochondrial population. In this study, we confirmed that HM are considerably compromised in their structure. In fact, HM showed to have the highest hydroperoxide content and the most consistent modifications in their fatty acid pattern with wide loss of fatty acids (or part of them) in the phospholipid moiety. Such situation could explain the typical impairment of HM and could support the hypothesis that they represent an old mitochondrial population.

Keywords

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Structural Damage Induced by Peroxidation May Account for Functional Impairment of Heavy Synaptic Mitochondria

Information for

Open access

Opportunities

Help and information

Structural Damage Induced by Peroxidation May Account for Functional Impairment of Heavy Synaptic Mitochondria

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature