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Original

Lipid peroxidation, antioxidant status and survival in institutionalised elderly: A five-year longitudinal study

, , , &
Pages 571-578 | Received 21 Oct 2005, Published online: 07 Jul 2009
 

Abstract

Oxidative stress has been related to ageing and risk of death. To determine whether oxidative status was associated with all-cause risk of death we carried out a prospective study in 154 non-smoking Spanish elderly without major illness. Baseline glutathione peroxidase (GPx) and superoxide dismutase (SOD) were analysed in plasma and erythrocytes. α-tocopherol, β-carotene, lycopene and retinol were determined in serum samples and malondialdehyde (MDA), as a lipid peroxidation marker, in plasma. Mean survival time was 4.3 years. A total of 31 death cases (20.1%) occurred during the follow-up. Plasma-MDA predicted mortality independently of all other variables, while erythrocyte-SOD (e-SOD), β-carotene and α-tocopherol were positively associated with survival. α-tocopherol and MDA were revealed as independent predictors in a joint survival model, being the group with low MDA and high α-tocopherol that with the lowest mortality. In conclusion, a higher risk of death was associated with increased lipid peroxidation and lower antioxidant defenses.

Abbreviations
BMI=

body mass index

DNA=

deoxyribonucleic acid

e-GPx=

erythrocyte-glutathione peroxidase

p-GPx=

plasma-glutathione peroxidase

HPLC=

high-performance liquid chromatography

MDA=

malondialdehyde

e-SOD=

erythrocyte-superoxide dismutase

p-SOD=

plasma-superoxide dismutase

Abbreviations
BMI=

body mass index

DNA=

deoxyribonucleic acid

e-GPx=

erythrocyte-glutathione peroxidase

p-GPx=

plasma-glutathione peroxidase

HPLC=

high-performance liquid chromatography

MDA=

malondialdehyde

e-SOD=

erythrocyte-superoxide dismutase

p-SOD=

plasma-superoxide dismutase

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