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Abstract
It has been demonstrated that spray-drying is a powerful method to prepare dry powders for pulmonary delivery. This paper prepared dispersible dry powders based on chitosan and mannitol containing honokiol nanoparticles as model drug. The results showed that the prepared microparticles are almost spherical and have appropriate aerodynamic properties for pulmonary delivery (aerodynamic diameters was between 2.8–3.3 μm and tapped density ranging from 0.14–0. 18 g/cm3). Moreover, surface morphology and aerodynamic properties of the powders were strongly affected by the content of mannitol. Fourier transform infra-red (FTIR) spectrum of powders indicated that the honokiol nanoparticles were successfully incorporated into microparticles. In vitro drug release profile was also observed. The content of mannitol in powders significantly influenced the release rate of honokiol from matrices.
Acknowledgements
Here we would like to show our great thanks to Jing Zheng (Library of Chengdu University of Information Technology) for her great help in proof-reading and correcting the manuscript.
This work was financially supported by National 863 project (2007AA021902), National Natural Science Foundation of China (NSFC20704027), Sichuan Key Project of Science and Technology (2007SGY019), Sichuan Prominent Young Talents Program (07ZQ026-033), and Chinese Key Basic Research Program (2004CB518807).
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.