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Abstract
Background: Osseogate is a novel drug delivery route through bone marrow involving a modified implant used as the drug delivery system. The purpose of this study was to evaluate the effects of individual drug physicochemical characteristics on the pharmacokinetic behavior when using the Osseogate as administration route.
Methods: Implant-mediated drug delivery systems (IMDDS) were installed in a total of 18 rabbits. After complete healing, water-soluble metformin hydrochloride was administered to one group (n = 9) while poorly soluble dexamethasone was administered to the other group (n = 9). The release patterns of each group were monitored for two weeks by measuring the plasma concentration of each drug.
Results: Both groups showed relative sustained release. However, metformin hydrochloride showed more rapid diffusion and early termination of drug release compared with dexamethasone.
Conclusions: The physicochemical properties of drugs significantly affected the release pattern through Osseogate. Further research is required to achieve controlled delivery using this route.
Acknowledgements
The authors are thankful to Professor Joo-Youn Cho (Seoul National University College of Medicine) for the assistance in performing liquid chromatography tandem mass spectroscopy.
Declaration of interest
The authors declare that they have no conflict of interests.
Funding
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2013R1A1A2074617).
Ethics approval
In this study, animal selection, management and surgical protocols were conducted according to routine procedures approved by the Institutional Animal Care and Use Committee of Seoul National University, Seoul, Korea.