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Abstract
Intramuscular (i.m.) immunization of mice with microencapsulated infectious rotavirus delayed protection against rotavirus challenge. Whereas unencapsulated rotavirus induced protection 6 but not 16 weeks after i.m. immunization, microencapsulated rotavirus induced protection 16 but not 6 weeks after i.m. immunization. Protection 16 weeks after immunization was associated with increased production of virus-specific immunoglobulin G (IgG) by small intestinal lamina propria (LP) lymphocytes. These findings demonstrate that i.m. immunization with microencapulated rotavirus can delay the onset of protection against challenge and the development of intestinal humoral immune responses. Simultaneous i.m. immunization with both unencapsulated and microencapsulated virus may induce prolonged protection from an intestinal pathogen, thus obviating the need for booster doses. Possible mechanisms of delayed protection induced by i.m. immunization with microencapsulated immunogens are discussed.
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