Studies on the Resuscitative Efficacy of Polymerized Bovine Hemoglobin

Abstract

The paper described modified hemoglobin (Hb) with glycolaldehyde for the efficacy on resuscitation of severe hemorrhagic shock. Our objective was to compare the effect on resuscitation of severe hemorrhagic shock with different experimental groups. Results showed early resuscitation with modified bovine Hb is superior to lactated Ringer's solution group in improving hemodynamic and acidosis, but the effect of polymerized Hb with glycolaldehyde were similar to fresh whole blood in this rat model.

Key Words:

• Resuscitation
• Hemorrhagic shock
• Base deficit
• Blood substitute