CERIUM(IV)-BASED CHEMILUMINESCENCE OF FELODIPINE SENSITIZED BY RHODAMINE 6G

Abstract

A simple, rapid, and sensitive flow injection chemiluminescence (FI-CL) method was proposed for the determination of felodipine. The method was based on the CL-emitting reaction between the studied drug and cerium(IV) in a nitric acid medium and measurement of the CL intensity produced by rhodamine 6G used as a sensitizer. Under the optimum conditions, the proposed procedure had a linear range between 5.0 × 10⁻⁹ and 7.0 × 10⁻⁶ g mL⁻¹, with a detection limit of 2.0 × 10⁻⁹ g mL⁻¹. The relative standard deviation was 2.3% for 1.0 × 10⁻⁷ g mL⁻¹ felodipine solution (n = 11). It was applied to the determination of felodipine in pharmaceutical preparations and biological fluids with satisfactory results. The possible mechanism of the chemiluminescence reaction was also discussed briefly.

Keywords:

• cerium(IV)
• chemiluminescence
• felodipine
• flow-injection

ACKNOWLEDGMENT

The authors gratefully acknowledge financial support from Shihezi University.

Notes

RSD, relative standard deviation.