Abstract
This year marks the 50th Anniversary of the founding of the Microcirculation Society. Since the formation of this society this field has witnessed tremendous progress in understanding the process of leukocyte recruitment during inflammation, injury, and immune reactions. This topic has been an important focus of many of the members of the Microcirculation Society as well as our colleagues worldwide. The goal of this brief review is to bring attention to a few emerging topics in inflammation research. Here the focus is on one particular model of how one leukocyte type (PMN) can regulate the recruitment of a second different leukocyte type (T cell) and provide an outline of other aspects that bear on spatial and temporal behavior of specific leukocyte and endothelial cell adhesion molecules during leukocyte transmigration under dynamic shear flow in vitro.
We thank our colleagues in the Vascular Research Division, Brigham and Women's Hospital, for helpful discussions during this work and the NIH for the funding that enabled us to carryout this project. We also thank William Jackson for the invitation to present our work at the 50th Anniversary Celebration for the Microcirculation Society, held 16 April 2004 at the National Institutes of Health, Bethesda, MD. Sources of support: National Institutes of Health Grants HL36028, HL53993, HL65090 (FWL), and an Arthritis Research Campaign Travelling Fellowship (RMR).